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汪 晴

来源:本站原创2015年12月07日

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  • 工作单位

    大连理工大学制药科学与技术学院

  • 研究方向

    现代给药技术与功能性药用材料

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    0411-84986176

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  • 姓名

    汪 晴

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专家简介


工作学习经历: PROFESSIONAL EXPERIENCE
1997年进入日本国立九州工业大学大学院,师从于缓控释给药( Drug Delivery System, DDS)领域知名的KAKUJI TOJO教授(AAPS创始人会员,Eur.J. Pharma.&Biopharma.编委)学习,2003 年取得博士学位,2003 年4月受聘大连理工大学副教授,2010年任大连理工大学教授。现任大连理工大学制药科学与技术学院教授博士生导师,现代给药系统与功能性材料学术带头人。
 
In 1997, Enrolled in Kyushu Institute of Technology in Japan, learned the technology of drug delivery. Obtained doctor degree in 2003. Worked in Dalian University of Technology since 2003, engaged in teaching and research work.Now, Hold Professor in Pharmacy Science and Technology Insititute, DLUT,Doctoral supervisor, Director in Modern DDS & Functional Material Group.
 
主要学术兼职: PLURALITY
1.教育部科研基金和科技奖励评审专家
2.国家食品药品监督管理总局 新药评审和化妆品审评专家;
3.国家重大新药创制项目审评(验收)专家;
4.世界中医药学会联合会新型给药技术专业委员会常务理事;
5.辽宁省保健品化妆品专家委员会委员;
6.大连市优秀专家;
7.中文核心期刊《中国实验方剂学杂志》和《中国医药技术经济与管理》编委;《International Journal of Pharmaceutical Science》,《Molecule Pharmaceutics》等英文杂志审稿人
 
1.Expert for Research Fund and technology award evaluation of Ministry of Education China;
2.Expert for the New Drug Assessment Centre of State of Food and Drug Administration;
3.Expert for Cosmetic Assessment Centre of State of Food and Drug Administration;
4.Director of the World Association of Traditional Chinese Medicine Association the Professional
5.Committee on the New Drug Administration Technology;
6.Committeeman in Chinese Medicine Research Association Professional Committee of TCM
7.Outstanding Expert of Dalian City
8.Editor for Chinese Journal of Pharmaceutical Technology Economics & Management;
9.Editor for China Journal of Experimental Traditional Medical Formulae.
10.Reader for 《 International Journal of Pharmaceutical Science》 ,《 Molecule Pharmaceutics》 and etc.
 
研究领域和方向: SPECIALITY AND RESEARCH FIELD
研究领域:现代给药技术与功能性药用材料
研究方向: 1、功能性材料及缓控释给药系统的研究
—压敏胶载药基质设计与合成研究;
—原位凝胶给药材料
2、 经皮给药计算机模拟与 PK/PD 相关性研究
— 经皮给药系统的设计与优化;
— 药物(有效成分) 跨膜渗透动力学研究;
3、生物大分子经皮/跨膜给药系统研究
— 生物大分子经皮/跨膜转运机理与促渗技术;
— 生物大分子经皮经粘膜转运的 in vitro 评价体系建立。
4、药品、保健食品化妆品组方、工艺及质量标准研究
 
Research Fields:
1. Functional Material and controlled/sustained delivery system:
— Design and Synthesis of Press Sensitive Adhesive for TTS;
— In Situ Gel Material ;
2. Computer Simulation and PK/PD Correlation of TTS
— Transdermal-CAD and Optimization Design
— Percutaneous Permeation Dynamics of Drugs;
3. Biomacromolecule Transdermal and Trans-Mucosa Delivery System
— Permeation Enhancement Technology and Mechanism;
— in vitro Evaluation Method for Transdermal and Trans-Mucosa System of
Biomacromolecule;
 
科研课题: RESEARCH PROJECT
近三年负责国家级科研项目
1、国家十一五重大新药创制项目《中药 TTS 给药系统关键技术研究与评价》
( 2009ZX09502-010) 项目组长
2、国家十二五重大新药创制项目《适用于中药的新型辅料研究》
( 2011ZX09501-001-02 ) 课题技术负责人,副组长 新型系列两亲性热熔压敏胶
结构设计与材料的性能评价。
3、国家十一五科技支撑计划重点项目《止痛活血类中药给药关键技术及评价方法
研究》( 2006BAI09B08-12) 课题负责人
4、国家自然科学基金《基于特异性促渗的芍甘非均相经皮给药系统设计及评价》
( 30873448) 课题负责人
5、国家自然科学基金《基于 MEMS 技术的载药聚合物微针 TTS 给药系统研究》
( 60976081) 合作单位负责人
 
National research projects
1. China Eleventh 5-years Plan —Great projects of major national drug, " Evaluation
of key technology for new traditional Chinese medicine transdermal delivery
system " Project leader
2. China Twelfth 5-year Plan—Great projects of major national drug, " Evaluation of
key technology for new traditional Chinese medicine transdermal delivery system "
Project technology leader
3. National Eleventh Five-Year key project of science and technology support
program, " Investigation of key technology and evaluation method for the Chinese
Traditional Drugs alleviate pain and promoting blood flow activity transdermal
delivery," sub-project leader
4. National Natural Science Foundation of China "based on specific penetration of
heterogeneous Shaogan transdermal delivery system design and evaluation" Project
leader
5. National Natural Science Foundation of China "based on polymer MEMS
drug-loaded microneedle transdermal drug delivery system " Cooperator
 
近三年论文、专利和特邀报告: PAPER、PATENT AND INVITED SPEECH ( last three years)
 
期刊论文
1. Xiao Tong, Qing Wang*, Hai-xia Wang, Xiao-Hui Li*, Wei Wu, Xin-yi Che Fabrication of pH Sensitive Amphiphilic Hot-Melt Pressure Sensitive Adhesives for Transdermal Drug Delivery System International Journal of Adhesion & Adhesives 48, p217-223, 2014 on line SCI IF:2.17
2. Xiao-Hui Li, Mei-Ling Huang, Shi-Miao Wang, Qing Wang* Selective Inhibition of Bicyclic Tetrapeptide Histone Deacetylase Inhibitor on HDAC4 and K562 Leukemia Cell Asian Pacific Journal of Cancer Prevention, 14(9), 2013 SCI IF:1.27
3.Mingming Chang, Xiaohui Li,* Yuming Sun, Fang Cheng,Yueqing Li, Weijie Zhao and Qing Wang* A Potential Mechanism of a Cationic Cyclopeptide for Enhancing Insulin Delivery across Caco-2 Cell Monolayers Biol. Pharm. Bull. 36(10), p1602–1607, 2013 SCI IF:1.85
4.Yongnan Hu, Qing Wang* , Yuming Sun, Xiaohui Li* , Xinyi Che, Haihong Zhang Studies on In Vitro Release Performance of Hydrophilic Drugs and Lipophilic Drugs in Amphiphilic SIS-Based Hot-Melt Pressure Sensitive Adhesives Applied Mechanics and Materials Vols. 395-396 , p389-398, 2013 EI
5.Mingming Chang, Xiaohui Li, Yuming Sun, Fang Cheng, Qing Wang*, Xiaohuan Xie, Weijie Zhao, and Xin Tian, Effect of Cationic Cyclopeptides on Transdermal and Transmembrane Delivery of Insulin, Molecular Pharmaceutics, 10(3) , p951-957, 2013 SCI IF:5.634
6.Zhong-fu Zhao, Bing Fang, Xiaohui Li, Qing Wang*, Development of hot-melt pressure sensitive adhesives for transdermal drug delivery, Journal of Adhesion Science and Technology, 27(2), p143-153, 2013 SCI IF:1.048
7.Qing Wang, Yong-zhao Wang, Zhong-fu Zhao*, Bing Fang, Synthesis of SIS-based hot-melt pressure sensitive adhesives for transdermal delivery of hydrophilic drugs, International Journal of Adhesion and Adhesives. 34, p62–67, 2012 SCI IF:2.345
8.J.J. Hao, Y.M. Sun, Qing Wang*, Xiao Tong, Hua Zhang, Qing Zhang, Effect and mechanism of penetration enhancement of organic base and alcohol on Glycyrrhetinic acid in vitro, International Journal of Pharmaceutics 399, p102–108, 2010 SCI IF:3.874
9.Li-li Hua, Yang Li, Qing Wang*, Yong-nan Hu, Zhong-fu Zhao*, Fabrication of amphiphilic hot-melt pressure sensitive adhesives for transdermal drug delivery, Journal of Adhesion Science and Technology , 26, 8-9, p1109-1122, 2012. SCI IF:1.048
10.Wang Q, Li ZJ, Sun L, Gao LY, Li MH, Hao JJ, Zhang X, Sun YM*., Pharmacokinetic study of lappaconitine hydrobromide in mice by LC-MS. Acta Pharmaceutica Sinica. 46 (4) , p432-437, 2011
11.姜博海,汪 晴,王世盛,蔡 蕊,赵伟杰* 应用近红外光谱法建立伤疖膏制备过程中黄芩苷的含量模型[J] 光谱学与光谱分析33 (01): 74-77 2013
12.孙玉明 杨洋 李冬 蒲婷婷 谢晓环 汪晴* 芍药苷对甘草酸及甘草次酸大鼠体内药代动力学的影响[J] 中国药学学报 47,8, 599-603, 2012.
13.张欣, 孙玉明, 汪晴*, 赵忠夫, 胡勇男, DOP对SIS型热熔压敏胶软化温度及体外释药性能的影响[J]. 中国医药工业杂志,( 41) 11 p37-41, 2010.
14.常明明, 孙玉明, 汪晴*, 钱勇, 张欣, 王天富 止痛活血压敏胶贴片中有效成分的体外释放研究[J] 中成药 32(1) p43-47, 2010
15.孟昱 汪晴 蔡蕊 李梅 孟庆刚 赵伟杰 保健品中枸橼酸西地那非成分近红外快速定性定量分析[J]. 大连理工大学报 ,2010, 06:867 -870.
16. Studies in Fabrication of Amphiphilic Hot-Melt Pressure Sensitive Adhesives and Applicability for Transdermal Drug Delivery EXCIPIENTFEST ASIA Beijing 2012.11
 
专利:
1. 汪晴 等.控释软膏组合基质及其制备方法,2010.8.25,中国, ZL2007 1 0011196.4
2. 汪晴 等.两亲性热熔压敏胶及其制备方法,2012.7.25,中国, ZL2010 1 0242108.3
3. 汪晴 等.用于促进甘草次酸经皮渗透组合物,2012.1.4,中国, ZL2010 1 0242109.
4. 汪晴 等.一种含有芍药苷和甘草次酸制剂及其制备方法,2012.5.30,中国,
ZL2011 1 0184048.9
5. 汪晴 等.一种格拉司琼和其盐酸盐制剂,2013.2.6,中国, ZL2008 1 0228371.X
6. 汪晴等 一种具有镇痛抗炎作用的苯甲酰基乌头原碱凝胶剂 ZL200910220428.6
7. 汪晴等 一组具有促进经皮和跨膜渗透作用的多肽及其应用 ZL201310052658.2
 
国际会议:
1. Studies in Fabrication of Amphiphilic Hot-Melt PSA dhesives andApplicability for Transdermal Drug Delivery EXCIPIENTFEST ASIA Beijing 2012.11


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